Journal article
Serous ovarian and primary peritoneal cancers: A comparative analysis of clinico-pathological features, molecular subtypes and treatment outcome
B Gao, K Lindemann, L Anderson, S Fereday, J Hung, K Alsop, RW Tothill, V Gebski, C Kennedy, RL Balleine, PR Harnett, DDL Bowtell, A DeFazio
Gynecologic Oncology | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2016
Abstract
Objective Primary peritoneal cancer is rare and considered equivalent to stage III/IV ovarian cancer, but questions remain concerning its underlying biology, prognosis and optimal management. Methods Clinico-pathological and treatment details of primary peritoneal (n = 120) and ovarian cancer (n = 635) were obtained on women recruited to the Australian Ovarian Cancer Study. Log-rank test was used to compare survival and cox proportional hazards models were fitted to obtain hazard ratios and 95% confidence intervals, both unadjusted and adjusted for age, grade, FIGO stage, residual disease and treatment with neoadjuvant chemotherapy. Molecular subtype was determined by gene expression profili..
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Awarded by Medical Research and Materiel Command
Funding Acknowledgements
The Australian Ovarian Cancer Study was supported by the U.S. Army Medical Research and Materiel Command under DAMD17-01-1-0729, The Cancer Council Victoria, Queensland Cancer Fund, The Cancer Council New South Wales, The Cancer Council South Australia, The Cancer Foundation of Western Australia, The Cancer Council Tasmania and the National Health and Medical Research Council of Australia (NHMRC: ID400413, ID40028). AdeF is funded by the University of Sydney Cancer Research Fund and the Cancer Institute NSW through the Sydney-West Translational Cancer Research Centre.